We find that electroencephalographic recordings reveal epileptiform abnormalities in some BACE1 -/- mice, occasionally including generalized tonic-clonic and absence seizures. Here we report a seizure-susceptibility phenotype that we have identified and characterized in BACE1 -/- mice. Examination of BACE1 -/- mice can provide insight into this function and also help anticipate consequences of BACE1 inhibition. ![]() While BACE1 is an attractive therapeutic target, its normal physiological function remains largely unknown. BACE1 is a key enzyme in the generation of the Aβ peptide that plays a central role in the pathogenesis of Alzheimer's disease.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |